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KMID : 1094020160330060395
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Journal of Veterinary Clinics
2016 Volume.33 No. 6 p.395 ~ p.399
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Combination Chemotherapy of Carboplatin and Cyclophosphamide in a Dog with Mammary Tumors Metastasized to the Lungs
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Ryu Jae-June
Kim Ill-Hwa
Kang Hyun-Gu
Hwang Dae-Youn
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Abstract
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In the present case, the effect and toxicity of carboplatin and cyclophosphamide chemotherapy combinedwith surgery of mammary tumors in a dog were examined. An 8-year old spayed female Beagle presented with amammary tumor. Physical examination, radiography, ultrasonography, computed tomography (CT), and laboratoryexamination were performed. Metastasis of the mammary tumor was confirmed by CT scan. Chemotherapy using acombination of carboplatin and cyclophosphamide was initiated following surgery. The first cycle of chemotherapywas planned to last for 6 weeks; it was planned that carboplatin would be intravenously administered for the firstweek (1 day) and cyclophosphamide would be intravenously administered for the next 3 weeks (22 days). Betweenthe end of cycle 1 and the beginning of cycle 2, based on CT, it was confirmed that the number and size of tumorswere unchanged and the tumors had not spread to other organs. However, at the end of cycle 2 and the beginningof cycle 3, CT revealed an increase in the number and size of mass in the lung. Chemotherapy was associated withadverse effects such as lethargy, anorexia, leukopenia, and hair loss. In conclusion, this case showed that a combinationof carboplatin and cyclophosphamide suppressed the development of new neoplasms as well as metastasis for a certainperiod of time but did not improve the survival time. Although more cases are required, this chemotherapeutic procedureremains challenging.
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KEYWORD
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dog, chemotherapy, carboplatin, cyclophosphamide, mammary tumor
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